PRP有助於慢性放射性傷口的護理
PRP可有效促進放射線皮膚炎癒合
在使用輻射線照射的狀況下，研究內皮細胞和脂肪幹細胞與PRP的交互作用，並檢測細胞表面標記 CD90 和 CD31 的表現量並分析PRP對於外部輻射線照射後的細胞增殖和活力狀況，得出共同使用脂肪幹細胞和 PRP 產品有助於慢性放射性傷口的護理。
PRP科技新知- PRP有助於慢性放射性傷口的護理
研究背景:
PRP可以經由促進血管生成的作用，進而促進慢性傷口的癒合。微血管損害是放射線傷口不易癒合的主要因素。迄今為止，PRP對於放射性皮膚傷口癒合過程的作用機轉所知甚少。
研究方法:
此篇文章使用輻射線照射的狀況下，研究內皮細胞和脂肪幹細胞(adipose-derived stem cells, ASC)與PRP的交互作用，並檢測細胞表面標記 CD90 和 CD31 的表現量。此外，並分析PRP對於外部輻射線照射後的細胞增殖和活力狀況。
結論: 共同使用脂肪幹細胞和 PRP 產品有助於慢性放射性傷口的護理。
原文摘要:
Platelet-rich plasma is a current subject of studies on chronic wound healing therapy due to possible pro-angiogenic effects. Microvascular compromise represents the major component in radiogenic wound healing complications. The effects of platelet-rich plasma on irradiated cells of the cutaneous wound healing process are poorly understood so far. In this study, the interaction of endothelial cells and adipose-derived stem cells in conjunction with treatment with platelet-rich plasma is investigated in the context of radiation effects. Therefore, the expression of surface-marker CD90 and CD31 was determined. Moreover, cell proliferation and viability after external radiation was analyzed with and without treatment by platelet-rich plasma.
文章出處:
Reinders Y, Felthaus O, Brockhoff G, Pohl F, Ahrens N, Prantl L, Haubner F: Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation. Int J Mol Sci 2017, 18(
.
研究背景:
PRP可以經由促進血管生成的作用，進而促進慢性傷口的癒合。微血管損害是放射線傷口不易癒合的主要因素。迄今為止，PRP對於放射性皮膚傷口癒合過程的作用機轉所知甚少。
研究方法:
此篇文章使用輻射線照射的狀況下，研究內皮細胞和脂肪幹細胞(adipose-derived stem cells, ASC)與PRP的交互作用，並檢測細胞表面標記 CD90 和 CD31 的表現量。此外，並分析PRP對於外部輻射線照射後的細胞增殖和活力狀況。
結論: 共同使用脂肪幹細胞和 PRP 產品有助於慢性放射性傷口的護理。
原文摘要:
Platelet-rich plasma is a current subject of studies on chronic wound healing therapy due to possible pro-angiogenic effects. Microvascular compromise represents the major component in radiogenic wound healing complications. The effects of platelet-rich plasma on irradiated cells of the cutaneous wound healing process are poorly understood so far. In this study, the interaction of endothelial cells and adipose-derived stem cells in conjunction with treatment with platelet-rich plasma is investigated in the context of radiation effects. Therefore, the expression of surface-marker CD90 and CD31 was determined. Moreover, cell proliferation and viability after external radiation was analyzed with and without treatment by platelet-rich plasma.
文章出處:
Reinders Y, Felthaus O, Brockhoff G, Pohl F, Ahrens N, Prantl L, Haubner F: Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation. Int J Mol Sci 2017, 18(
.